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在线速递胸腺肽1T1通过恢复
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Thymosinalpha1(Tα1)reducesthemortalityofsevereCOVID-19byrestorationoflymphocytopeniaandreversionofexhaustedTcells
YuepingLiu1#,YuePang2#,ZhenhongHu3#,MingWu4,5,ChenhuiWang2,ZeqingFeng2,CongzhengMao3,YingjunTan2,YingLiu1,LiChen1,MinLi1,GangWang1,ZilinYuan1,BoDiao1*,YuzhangWu2*,YongwenChen2*
Abstract摘要
Background背景
WepreviouslyreportedthatlymphocytopeniaandTcellexhaustionisnotableinacuteCOVID19patients,especiallyinagedandseverecases.Thymosinalpha1(Tα1)hadbeenusedinthetreatmentofviralinfectionsasanimmuneresponsemodifierformanyyears.However,clinicalbenefitsandmechanismofTα1supplementtoCOVID-19arestillunclear.
我们先前曾报道，在急性COVID-19患者中存在显著的淋巴细胞减少和T细胞衰竭，特别是在老年和重症患者中。胸腺肽α1（Tα1）作为一种免疫应答调节剂已用于治疗病毒感染多年。然而，COVID-19患者补充Tα1的临床疗效和机制尚不清楚。
Methods方法
Weretrospectivelyreviewedtheclinicalout
